| #P001 | chemical | health | guideline | Tetrachloroethylene | drinking water | unknown | 0.015 mg/L | Calculated health-based value (HBV) for hepatocellular tumours (cancer risk assessment) | Derived using TDI of 0.0068 mg/kg bw per day, 70 kg adult body weight, 0.2 allocation factor, and 6.2 L-eq/day consumption. | high |
| #P002 | chemical | health | guideline | Tetrachloroethylene | drinking water | unknown | 0.010 mg/L | Calculated health-based value (HBV) for neurological effects (non-cancer risk assessment). Considered sufficiently protective of carcinogenic effects. | Derived using TDI of 0.0047 mg/kg bw per day, 70 kg adult body weight, 0.2 allocation factor, and 6.2 L-eq/day consumption. | high |
| #P003 | chemical | health | guideline | Tetrachloroethylene | drinking water | unknown | 40 µg/L | WHO drinking water guideline | Based on a NOAEL for hepatotoxic effects from a 6-week gavage study in mice and a 90-day drinking water study in rats. | high |
| #P004 | chemical | health | guideline | Tetrachloroethylene | drinking water | unknown | 50 µg/L | Australian drinking water guideline | | high |
| #P005 | chemical | health | mandatory | Tetrachloroethylene | drinking water | MAC | 0.005 mg/L | U.S. EPA maximum contaminant level (MCL) under National Primary Drinking Water Regulations | Designed to be protective of liver problems and increased risk of cancer. | high |
| #P006 | chemical | health | guidance | Tetrachloroethylene | drinking water | unknown | 0 mg/L | U.S. EPA maximum contaminant level goal (MCLG) | | high |
| #P007 | chemical | health | guidance | Tetrachloroethylene | drinking water | unknown | 0.06 µg/L | Office of Environmental Health Hazard Assessment of the California EPA (OEHHA) non-regulatory public health goal | Based on hepatocellular carcinomas in mice and mononuclear cell leukaemia in rats. | high |
| #P008 | chemical | health | guidance | Tetrachloroethylene (Cancer Risk Concentration) | drinking water | treatment_goal | 20 µg/L | US EPA estimate for concentration in drinking water associated with a 10-6 excess risk | based on hepatocellular adenomas and carcinomas from the JISA (1993) study | high |
| #P009 | chemical | health | guidance | Tetrachloroethylene (Oral Reference Dose) | drinking water | treatment_goal | 6 µg/kg bw per day | US EPA Integrated Risk Information System (IRIS) oral reference dose | based on the average value for two separate neurological endpoints (Cavalleri et al., 1994; Echeverria et al., 1995) | high |
| #P010 | chemical | health | guidance | Tolerable Daily Intake (TDI) - Cancer | drinking water | requirement | 0.0068 mg/kg bw per day | Calculated TDI based on hepatocellular tumours for cancer risk assessment. | Derived from BMDL10 of 1.7 mg/kg bw per day and a total uncertainty factor of 250. | high |
| #P011 | chemical | health | guidance | Tolerable Daily Intake (TDI) - Non-cancer | drinking water | requirement | 0.0047 mg/kg bw per day | Calculated TDI based on neurological effects for non-cancer risk assessment. | Derived from external oral dose associated with BMDL10 (4.7 mg/kg bw per day) and 1000-fold uncertainty factor. | high |
| #P012 | chemical | health | guidance | No-observed-adverse-effect level (NOAEL) - Neurotoxicity | drinking water | unknown | 4.8 ppm | Key study NOAEL for colour confusion obtained from the neurological assessment. | Based on inhalation exposures from Cavalleri et al. (1994). | high |
| #P013 | chemical | health | guidance | Benchmark dose lower confidence limit (BMDL10) - Cancer | drinking water | requirement | 1.7 mg/kg bw per day | External dose associated with the lower 95% confidence limit on a 10% increase in hepatocellular tumours (NTP 1986 study). | Calculated using a multistage model. | high |
| #P014 | chemical | health | guidance | Benchmark dose (BMD10) - Neurotoxicity | drinking water | requirement | 7.2 ppm | Inhalation exposure level representing a 10% increase in colour confusion adverse effects. | Calculated using the power model based on Cavalleri et al. (1994). | high |
| #P015 | chemical | health | guidance | Benchmark dose lower confidence limit (BMDL10) - Neurotoxicity | drinking water | requirement | 6.6 ppm | Inhalation exposure associated with the lower 95% confidence limit on a 10% increase in colour confusion. | Calculated using the power model based on Cavalleri et al. (1994). | high |
| #P016 | chemical | health | guidance | External oral dose associated with BMDL10 - Neurotoxicity | drinking water | requirement | 4.7 mg/kg bw per day | Extrapolated external oral dose from the inhalation BMDL10 using PBPK modelling. | Used peak concentrations of tetrachloroethylene in the kidney as a proxy for brain values. | high |
| #P017 | chemical | health | guidance | External Benchmark Dose (BMD10) - Cancer | drinking water | requirement | 6.2 mg/kg bw per day | External dose associated with a 10% increase in hepatocellular tumours (NTP 1986 study). | Calculated using a multistage model. | high |
| #P018 | chemical | health | guidance | Excess Cancer Risk Level Range | drinking water | requirement | 10-5 to 10-6 dimensionless | Default approach for cancer risk assessment for mutagenic compounds or those that cannot be excluded as being mutagenic. | Represents a risk range of 1 in 100,000 to 1 in 1,000,000. | high |